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KMID : 0359720220400020156
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Journal of the Korean Neurological Association
2022 Volume.40 No. 2 p.156 ~ p.159
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Neuronal Intranuclear Inclusion Disease with Abnormal Peripheral Nerve Conduction
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Jeong A-Yeong
Kim Young-Ho
Ryu Ho-Sung
Han Man-Hoon
Lee Jong-Mok
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Abstract
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A 70-year-old female presented with progressive gait disturbance. Neurologic examination revealed sensory impairment, hyporeflexia, and sensory ataxia. Nerve conduction study demonstrated mildly decreased velocity in motor nerves. Brain magnetic resonance imaging showed high signal intensities in the corticomedullary junction on diffusion weighted imaging.
Neurocognitive function test implied mild cognitive impairment. Based on eosinophilic intranuclear inclusions in pathology, neuronal intranuclear inclusion disease was confirmed. Neuronal intranuclear inclusion needs to be considered when abnormal nerve conduction studies are consistent with abnormal brain imaging findings.
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KEYWORD
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Neurodegenerative diseases, Intranuclear inclusion bodies, Leukoencephalopathies
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